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KMID : 0043319980210020157
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Archives of Pharmacal Research
1998 Volume.21 No. 2 p.157 ~ p.163
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Synthesis of Antineoplaston A10 Analogs as Potential Antitumor Agents
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Choi Bo-Gil
Cheon Seung-Hoon
Cho Won-Jea
Lee Chong-Ock
Chung Byung-Ho
Kim Ok-Young
Choi Sang-Un
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Abstract
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Several aniline mustard analogues were obtained by introducing N,N-bis(2-chloroethyl)amino moiety to phenyl ring of A10 analogues in order to increase reactivity of A10 analogs and selectivity into DNA. The in vitro antitumor activity of synthesized compounds was evaluated using five different solid tumor cell lines by SRB method. Aniline mustard analogues exhibited more potent antitumor activity than A10 analogs. Especially, m-aniline mustard of benzoyl analogue displayed remarkable antitumor activity.
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KEYWORD
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Antineoplaston A10, Aniline mustards, Piperidinedione derivatives, Antitumor agent
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